Zhang, X., et al., Subcutaneous injection of hydrogen gas is a novel effective treatment for type 2 diabetes. J Diabetes Investig, 2018. 9(1): pp. 83-90.

Korovljev, D., et al., Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women . Ir J Med Sci, 2017.

Hou, C., et al., Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer . Biochem Pharmacol, 2016. 103: p. 85-97.

Zong, C., et al., Cigarette smoke exposure impairs reverse cholesterol transport which can be minimized by treatment of hydrogen-saturated saline. Lipids Health Dis, 2015. 14: p. 159.

Song, G., et al., Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome . Journal of Lipid Research, 2013. 54(7): p. 1884-93.

Jiang, H., et al., Hydrogen-rich medium suppresses the generation of reactive oxygen species, elevates the Bcl-2/Bax ratio and inhibits advanced glycation end product-induced apoptosis . Int J Mol Med, 2013. 31(6): p. 1381-7.

Iio, A., et al., Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells . Medical Gas Research, 2013. 3(1): p. 6.

Ignacio, RM, et al., Anti-obesity effect of alkaline reduced water in high fat-fed obese mice. Biol Pharm Bull, 2013. 36(7): p. 1052-9.

He, B., et al., Protection of oral hydrogen water as an antioxidant on pulmonary hypertension. Mol Biol Rep, 2013. 40(9): p. 5513-21.

Fan, M., et al., Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin-induced diabetic rat model . Journal of Urology, 2013. 190(1): p. 350-6.

Chen, Y., et al., Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation and neointimal hyperplasia by inhibiting reactive oxygen species production and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways . International Journal of Molecular Medicine, 2013. 31(3): p. 597-606.

Baek, D.-H., Antibacterial Activity of Hydrogen-rich Water Against Oral Bacteria .

Amitani, H., et al., Hydrogen Improves Glycemic Control in Type 1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle. PLoS One, 2013. 8(1).

Zong, C., et al., Administration of hydrogen-saturated saline decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in high-fat diet-fed hamsters. Metabolism, 2012. 61(6): p. 794-800.

Zheng, H. and YS Yu, Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats. Biochemical Pharmacology, 2012. 83(9): p. 1269-77.

Yu, YS and H. Zheng, Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats . Mol Cell Biochem, 2012. 365(1-2): p. 233-42.

Wang, QJ, et al., Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress . Chin Med J (Engl), 2012. 125(9): p. 1633-7.

Tanabe, H., et al., Suppressive Effect of High Hydrogen Generating High Amylose Cornstarch on Subacute Hepatic Ischemia-reperfusion Injury in Rats. Biosci Microbiota Food Health, 2012. 31(4): p. 103-8.

Song, G., et al., Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein E knockout mice . Atherosclerosis, 2012. 221(1): p. 55-65.

Nishioka, S., et al., Effect of hydrogen gas inhalation on lipid metabolism and left ventricular remodeling induced by intermittent hypoxia in mice. European Heart Journal, 2012. 33: p. 794-794.

Kawai, D., et al., Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. Hepatology, 2012. 56(3): p. 912-21.

Fan, M., et al., Protective Effects of Hydrogen-Rich Saline Against Erectile Dysfunction in a Streptozotocin Induced Diabetic Rat Model . J Urol, 2012.

Ekuni, D., et al., Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model. Arch Oral Biol, 2012. 57(12): p. 1615-22.

Yu, P., et al., Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage. Biochemical and Biophysical Research Communications, 2011. 409(2): p. 350-5.

Yang, X., et al., Protective effects of hydrogen-rich saline in preeclampsia rat model . Placenta, 2011. 32(9): p. 681-6.

Wang, Y., et al., Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model . Respir Res, 2011. 12: p. 26.

Song, G., et al., H2 inhibits TNF-alpha-induced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear factor kappaB activation in endothelial cells . Biotechnology Letters, 2011. 33(9): p. 1715-22.

Shirahata, S., et al., Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticles . BMC Proc, 2011. 5 Suppl 8: p. Q18.

Nakai, Y., et al., Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water . Bioscience, Biotechnology, and Biochemistry, 2011. 75(4): p. 774-6.

Li, Y., et al., Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus . Cytotechnology, 2011. 63(2): p. 119-31.

Kamimura, N., et al., Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice . Obesity, 2011.

Hashimoto, M., et al., Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat – a metabolic syndrome rat model . Medical Gas Research, 2011. 1(1): p. 26.

Nakao, A., et al., Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome-An Open Label Pilot Study . Journal of Clinical Biochemistry and Nutrition, 2010. 46(2): p. 140-149.

Chen, CH, et al., Hydrogen Gas Reduced Acute Hyperglycemia-Enhanced Hemorrhagic Transformation in a Focal Ischemia Rat Model . Neuroscience, 2010. 169(1): p. 402-414.

Abe, M., et al., Suppressive Effect of ERW on Lipid Peroxidation and Plasma Triglyceride Level , in Animal Cell Technology: Basic & Applied Aspects, S. Netherlands, Editor. 2010, pp. 315-321.

Chao, YC and MT Chiang, Effect of alkaline reduced water on erythrocyte oxidative status and plasma lipids of spontaneously hypertensive rats . Taiwanese Journal of Agricultural Chemistry and Food Science, 2009. 47(2): pp. 71-72.

Ohsawa, I., et al., Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochem Biophys Res Commun, 2008. 377(4): pp. 1195-8.

Kajiyama, S., et al., Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance . Nutrition Research, 2008. 28: p. 137–143.

Kim, MJ, et al., Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic db/db mice . Biol Pharm Bull, 2007. 30(2): p. 234-6.

Yeunhwa GU, KO, Taigo FUj, Yuka ITOKAWA, et al., Anti Type 2 Diabetic Effect and Anti-oxidation Effect in Active Hydrogen Water Administration KK-Ay Mice. Medicine and Biology, 2006. 150(11): p. 384-392.

Kim, MJ and HK Kim, Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and genetic diabetic mice. Life Sci, 2006. 79(24): p. 2288-92.

Jin, D., et al., Anti-diabetic effect of alkaline-reduced water on OLETF rats. Biosci Biotechnol Biochem, 2006. 70(1): p. 31-7.

GU, HY, et al., Anti-oxidation Effect and Anti Type 2 Diabetic Effect in Active Hydrogen Water Medicine and Biology, 2006. 150(11): p. 384-392.

Dan, J., et al., Effect of mineral induced alkaline reduced water on sprague-dawley rats fed on a high fat diet . Exp. Biomed. Sci., 2006. 12: p. 1-7.

Li, Y.-P., Teruya, K., Katakura, Y., Kabayama, S., Otsubo, K., Morisawa, S., et al, Effect of reduced water on the apoptotic cell death triggered by oxidative stress in pancreatic b HIT-T15 cells . Animal cell technology meets genomics, 2005: p. 121-124.

Kim, H.-W., Alkaline Reduced Water produced by UMQ showed Anti-cancer and Anti-diabetic effect. published online at http://www.korea-water.com/images/e_q.pdf 2004 .

Hamaskai, T., et al., The suppressive effect of electrolyzed reduced water on lipid peroxidation . Animal Cell Technology: Basic & Applied Aspects, 2003. 13: p. 381-385.

Chiasson, JL, et al., Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial . JAMA, 2003. 290(4): p. 486-94.

Li, Y., et al., Protective mechanism of reduced water against alloxan-induced pancreatic beta-cell damage: Scavenging effect against reactive oxygen species . Cytotechnology, 2002. 40(1-3): p. 139-49.

Shirahata, S., Anti-oxidative water improves diabetes .

Oda, M., et al., Electrolyzed and natural reduced water exhibit insulin-like activity on glucose uptake into muscle cells and adipocytes . Animal Cell Technology: Products from Cells, Cells as Products, 2000: p. 425-427.

Nelson, D., et al., Effect of electrolyzed water intake on lifespan of autoimmune disease prone mice. Faseb Journal, 1998. 12(5): p. A794-A794.

Yokoyama, J.-mKaK, Effects of alkaline ionized water on spontaneously diabetic GK-rats fed sucrose. J. of Lab. Anim Sa, 1997. 13(2): p. 187-190.

Darnaud, C., [Indications for alkaline mineral water cure in diabetes mellitus] . Toulouse Med, 1951. 52(5): p. 277-84.

These scientific articles, although promising and interesting, do not represent clinical guidelines confirming that hydrogen can cure or prevent a particular disease. For medical questions, consult your doctor.

Yuan, J., et al., Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway . J Surg Res, 2018. 228: pp. 238-246.

Wu, X., et al., Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway . Brain Res, 2018.

Wang, H., et al., Hydrogen-Rich Saline Activated Autophagy via HIF-1alpha Pathways in Neuropathic Pain Model . Biomed Res Int, 2018. 2018: p. 4670834.

Varga, V., et al., Molecular hydrogen alleviates asphyxia-induced neuronal cyclooxygenase-2 expression in newborn pigs . Acta Pharmacol Sin, 2018.

Satoh, Y., et al., Molecular Hydrogen Prevents Social Deficits and Depression-Like Behaviors Induced by Low-Intensity Blast in Mice . J Neuropathol Exp Neurol, 2018.

Nishimaki, K., et al., Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment . Curr Alzheimer Res, 2018. 15(5): p. 482-492.

Jiang, X., et al., FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia. Behav Brain Res, 2018.

Imai, K., et al., Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model . Sci Rep, 2018. 8(1): p. 9221.

Huang, JL, WW Liu, and XJ Sun, Hydrogen inhalation improves mouse neurological outcomes after cerebral ischemia/reperfusion independent of anti-necroptosis . Med Gas Res, 2018. 8(1): p. 1-5.

Hou, C., et al., Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Abeta clearance . Free Radic Res, 2018: p. 1-12.

Choi, KS, et al., Neuroprotective effects of hydrogen inhalation in an experimental rat intracerebral hemorrhage model . Brain Res Bull, 2018. 142: p. 122-128.

Ono, H., et al., Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection . J Stroke Cerebrovasc Dis, 2017.

Nishimaki, K., et al., Effects of molecular hydrogen assessed by an animal model and a

randomized clinical study on mild cognitive impairment . Curr Alzheimer Res, 2017.

Yoshii, Y., et al., Complexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson's Disease Model Mice . Neurochem Res, 2017.

Yoneda, T., et al., Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption in Rats Fed a High-Fat Diet . Nutrients, 2017. 9(1).

Wen, D., et al., Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice. Neuropharmacology, 2017. 118: p. 199-208.

Shi, Y., et al., Hydrogen gas attenuates sevoflurane neurotoxicity through inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells signaling and proinflammatory cytokine release in neonatal rats. Neuroreport, 2017. 28(17): p. 1170-1175.

Murakami, Y., M. Ito, and I. Ohsawa, Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis . PLoS One, 2017. 12(5): p. e0176992.

Mizuno, K., et al., Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life . Med Gas Res, 2017. 7(4): p. 247-255.

Yoritaka, A., et al., Pilot study of H(2) therapy in Parkinson's disease: A randomized double-blind placebo-controlled trial . Movement Disorders, 2013.

Matsuoka, T., et al., Hydrogen gas inhalation inhibits progression to the "irreversible" stage of shock after severe hemorrhage in rats. J Trauma Acute Care Surg, 2017.

Ma, H., et al., [Hydrogen-rich saline attenuates hyperalgesia and reduces cytokines in rats with post-herpetic neuralgia via activating autophagy] . Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2017. 33(2): pp. 155-158.

Liu, Y., et al., Effect of hydrogen-rich water on the angiogenesis in lesion boundary brain tissue of traumatic brain injury-challenged rats . INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2017. 10(3): p. 3807-3815.

Li, D. and Y. Ai, Hydrogen saline suppresses neuronal cell apoptosis and inhibits the p38 mitogenactivated protein kinase caspase3 signaling pathway following cerebral ischemiareperfusion injury . Mol Med Rep, 2017. 16(4): p. 5321-5325.

Li, C., et al., Hydrogen-rich saline attenuates isoflurane-induced caspase-3 activation and cognitive impairment via inhibition of isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP levels . Am J Transl Res, 2017. 9(3): p. 1162-1172.

He, Y., et al., Image-guided hydrogen gas delivery for protection from myocardial ischemia-reperfusion injury via microbubbles. ACS Appl Mater Interfaces, 2017.

Gao, Q., et al., Molecular hydrogen increases resilience to stress in mice . Sci Rep, 2017. 7(1): p. 9625.

Zhao, M., et al., Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice . J Neuroimmunol, 2016. 294: p. 6-13.

Zhang, Y., et al., Effects of hydrogen-rich water on depressive-like behavior in mice . Sci Rep, 2016. 6: p. 23742.

Takaenoki, Y., et al., Neonatal exposure to sevoflurane in mice causes deficits in maternal behavior later in adulthood . Anesthesiology, 2014. 120(2): p. 403-15.

Yonamine, R., et al., Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice. Anesthesiology, 2013. 118(1): p. 105-13.

Zhang, Y., et al., Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis . Neurochem Res, 2016. 41(4): p. 770-8.

Zhang, L., et al., Hydrogen has a neuroprotective effect via activation of Nrf-2/HO-1 pathway in ischemia reperfusion rat . INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2016. 9(6): p. 10521-10528.

Yang, L., D. Li, and S. Chen, Hydrogen water reduces NSE, IL-6, and TNF-alpha levels in hypoxic-ischemic encephalopathy . Open Med (Wars), 2016. 11(1): p. 399-406.

Wang, X., et al., The protective effects of hydrogen on HO-1 expression in the brain after focal cerebral ischemia reperfusion in rats . Turk J Med Sci, 2016. 46(5): p. 1534-1539.

Tian, ​​R., et al., Hydrogen-rich water attenuates brain damage and inflammation after traumatic brain injury in rats . Brain Res, 2016. 1637: p. 1-13.

Shao, A., et al., Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-kappaB Pathway and NLRP3 Inflammasome . Mol Neurobiol, 2016. 53(5): p. 3462-3476.

Nemeth, J., et al., Molecular hydrogen affords neuroprotection in a translational piglet model of hypoxic-ischemic encephalopathy . J Physiol Pharmacol, 2016. 67(5): pp. 677-689.

Li, Q., et al., Neuroprotective Effect of Hydrogen-Rich Saline in Global Cerebral Ischemia/Reperfusion Rats: Up-Regulated Tregs and Down-Regulated miR-21, miR-210 and NF-kappaB Expression . Neurochem Res, 2016. 41(10): pp. 2655-2665.

Cui, J., et al ., Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia-reperfusion injury in rats – A possible new hydrogen resource for clinical use . Neuroscience, 2016. 335: p. 232-41.

Chen, X., et al., [Effects of hydrogen-rich water on the expression of aquaporin 1 in the cerebral cortex of rats with traumatic brain injury] . Zhonghua Wei Zhong Bing Ji Jiu Yi Xue, 2016. 28(5): p. 460-4.

Bai, X., et al., Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice. Brain Res, 2016. 1646: p. 410-7.

Zhang, YG, et al., Hydrogen-rich saline promotes motor functional recovery following peripheral nerve autografting in rats . Experimental and Therapeutic Medicine., 2015. 10(2).

Yu, Y., et al., Protective effect of hydrogen-rich medium against high glucose-induced apoptosis of Schwann cells in vitro . Mol Med Rep, 2015. 12(3): p. 3986-92.

Wei, R., et al., Hydrogen Suppresses Hypoxia/Reoxygenation-Induced Cell Death in Hippocampal Neurons Through Reducing Oxidative Stress . Cell Physiol Biochem, 2015. 36(2): p. 585-98.

Takeuchi, S., et al., Hydrogen improves neurological function through attenuation of blood-brain barrier disruption in spontaneously hypertensive stroke-prone rats . BMC Neurosci, 2015. 16: p. 22.

Shao, A., et al., Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-kappaB Pathway and NLRP3 Inflammasome . Mol Neurobiol, 2015.

Nakano, T., et al., Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury . J Clin Biochem Nutr, 2015. 57(3): p. 178-82.

Lin, CL, et al., Hydrogen-rich water attenuates amyloid beta-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells . Chem Biol Interact, 2015. 240: p. 12-21.

Han, L., et al., Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins . Brain Res, 2015.

Du, Z., et al., Three hydrogen-rich solutions protect against intestinal injury in uncontrolled hemorrhagic shock . Int J Clin Exp Med, 2015. 8(5): p. 7620-6.

Du, Z., et al., Effects of three hydrogen-rich liquids on hemorrhagic shock in rats . J Surg Res, 2015. 193(1): p. 377-82.

Chen, Y., et al., H2Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain . Inflammation, 2015. 38(5): p. 1835-46.

Zhang, L., et al., Hydrogen-rich saline controls remifentanil-induced hypernociception and NMDA receptor NR1 subunit membrane trafficking through GSK-3beta in the DRG in rats. Brain Res Bull, 2014. 106C: p. 47-55.

Wang, T., et al., Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats. Toxicol Appl Pharmacol, 2014.

Tomura, S., et al., Physiological effects of combination therapy of intracisternal infusion of magnesium sulfate solution and intravenous injection of hydrogen-enriched fluid in the rat. Bōei Ika Daigakkō zasshi= Journal of the National Defense Medical College, 2014. 39: p. 96-102.

Mei, K., et al., Hydrogen protects rats from dermatitis caused by local radiation. J Dermatologist Treat, 2014. 25(2): p. 182-8.

Mano, Y., et al., Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion. Free Radic Biol Med, 2014. 69: p. 324-30.

Liu, L., et al., Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis. Brain Res, 2014. 1589: pp. 78-92.

Liu, FT, et al., Molecular Hydrogen Suppresses Reactive Astrogliosis Related to Oxidative Injury during Spinal Cord Injury in Rats. CNS Neurosci Ther, 2014.

Kashiwagi, T., et al., Electrochemically reduced water protects neural cells from oxidative damage . Oxid Med Cell Longev, 2014. 2014: p. 869121.

Hong, Y., et al., Neuroprotective effect of hydrogen-rich saline against neurological damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3beta signaling pathway. PLoS One, 2014. 9(4): p. e96212.

Dohi, K., et al., Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury. PLoS One, 2014. 9(9): p. e108034.

Cui, Y., et al., Hydrogen-rich saline attenuates neuronal ischemia-reperfusion injury by protecting mitochondrial function in rats . J Surg Res, 2014.

Zhuang, Z., et al., Nuclear factor-kappaB/Bcl-XL pathway is involved in the protective effect of hydrogen-rich saline on the brain following experimental subarachnoid hemorrhage in rabbits. J Neurosci Res, 2013. 91(12): p. 1599-608.

Shen, MH, et al., Neuroprotective effect of hydrogen-rich saline in acute carbon monoxide poisoning. CNS Neurosci Ther, 2013. 19(5): p. 361-3.

Olah, O., et al., Delayed neurovascular dysfunction is alleviated by hydrogen in asphyxiated newborn pigs. Neonatology, 2013. 104(2): p. 79-86.

Nagatani, K., et al., Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies . Med Gas Res, 2013. 3: p. 13.

Matsumoto, A., et al., Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice . Sci Rep, 2013. 3: p. 3273.

Manaenko, A., et al., Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice . Critical Care Medicine, 2013. 41(5): p. 1266-75.

Huang, G., et al., The neuroprotective effects of intraperitoneal injection of hydrogen in rabbits with cardiac arrest. Resuscitation, 2013. 84(5): p. 690-5.

Feng, Y., et al., Hydrogen-rich saline prevents early neurovascular dysfunction resulting from inhibition of oxidative stress in STZ-diabetic rats. Curr Eye Res, 2013. 38(3): p. 396-404.

Zhuang, Z., et al., Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits. BMC Neurosci, 2012. 13: p. 47.

Zhou, J., et al., Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture. Journal of Surgical Research, 2012. 178(1): p. 390-400.

Zhan, Y., et al., Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats. Critical Care Medicine, 2012. 40(4): p. 1291-6.

Wang, W., et al., Hydrogen rich saline reduces immune-mediated brain injury in rats with acute carbon monoxide poisoning. Neurological Research, 2012. 34(10): p. 1007-15.

Spulber, S., et al., Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness behavior in mice. PLoS One, 2012. 7(7): p. e42078.

Ji, X., et al., Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress. Journal of Surgical Research, 2012. 178(1): p. e9-16.

Ito, M., et al., Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson's disease in rats. Med Gas Res, 2012. 2(1): p. 15.

Hou, Z., et al., Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury. Brain Res Bull, 2012. 88(6): p. 560-5.

Hong, Y., et al., Beneficial effect of hydrogen-rich saline on cerebral vasospasm after experimental subarachnoid hemorrhage in rats. J Neurosci Res, 2012. 90(8): p. 1670-80.

Yan, H., et al., The neuroprotective effects of electrolyzed reduced water and its model water containing molecular hydrogen and Pt nanoparticles . BMC Proc, 2011. 5 Suppl 8: p. P69.

Wang, C., et al., Hydrogen-rich saline reduces oxidative stress and inflammation by inhibiting JNK and NF-kappaB activation in a rat model of amyloid-beta-induced Alzheimer's disease. Neuroscience Letters, 2011. 491(2): p. 127-32.

Ueda, Y., T. Kojima, and T. Oikawa, Hippocampal gene network analysis suggests that coral calcium hydride may reduce accelerated senescence in mice . Nutrition Research, 2011. 31(11): pp. 863-72.

Sun, Q., et al., Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity. Critical Care Medicine, 2011. 39(4): pp. 765-9.

Shen, L., et al., Hydrogen-rich saline is cerebroprotective in a rat model of deep hypothermic circulatory arrest. Neurochemical Research, 2011. 36(8): pp. 1501-11.

Ono, H., et al., Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study. Medical Gas Research, 2011. 1(1): p. 12.

Manaenko, A., et al., Hydrogen inhalation is neuroprotective and improves functional outcomes in mice after intracerebral hemorrhage. Acta Neurochir Suppl, 2011. 111: p. 179-83.

Liu, W., et al., Protective effects of hydrogen on fetal brain injury during maternal hypoxia . Acta Neurochir Suppl, 2011. 111: p. 307-11.

Kuroki, C., et al., Neuroprotective effects of hydrogen gas on brain in three types of stress models: A P-31-NMR and ESR study . Neuroscience Research, 2011. 71: p. E406-E406.

Kobayashi, H., et al., Effects of Hydrogen Gas in a Mouse Cold Induced Brain Injury Model. Journal of Neurotrauma, 2011. 28(5): pp. A64-A64.

Hugyecz, M., et al., Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. Brain Research, 2011. 1404: pp. 31-8.

Eckermann, JM, et al., Hydrogen is neuroprotective against surgically induced brain injury. Medical Gas Research, 2011. 1(1): p. 7.

Yokoi, I., Neuroprotective effects of hydrogen gas on brain in three types of stress models: a P-31 NMR and ESR study. Neuroscience Research, 2010. 68: pp. E320-E320.

Ueda, Y., A. Nakajima, and T. Oikawa, Hydrogen-Related Enhancement of In Vivo Antioxidant Ability in the Brain of Rats Fed Coral Calcium Hydride. Neurochemical Research, 2010. 35(10): p. 1510-1515.

Li, J., et al., Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress. Brain Res, 2010. 1328: p. 152-161.

Ji, X., et al., Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress. Brain Research, 2010. 1354: p. 196-205.

Hong, Y., S. Chen, and JM Zhang, [Research advances on hydrogen therapy in nervous system diseases] . Zhejiang Da Xue Xue Bao Yi Xue Ban, 2010. 39(6): p. 638-43.

Gu, Y., et al., Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-Accelerated Mice . Journal of Clinical Biochemistry and Nutrition, 2010. 46(3): p. 269-276.

Domoki, F., et al., Hydrogen is Neuroprotective and Preserves Cerebrovascular Reactivity in Asphyxiated Newborn Pigs. Pediatric Research, 2010. 68(5): p. 387-392.

Bari, F., et al., Inhalation of Hydrogen Gas Protects Cerebrovascular Reactivity Against Moderate but Not Severe Perinatal Hypoxic Injury in Newborn Piglets. Stroke, 2010. 41(4): p. E323-E323.

Nagata, K., et al., Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice. Neuropsychopharmacology, 2009. 34(2): p. 501-508.

Kuroki, C., et al., Neuroprotective effects of hydrogen gas on brain in three types of stress models : alpha P-31-NMR study. Neuroscience Research, 2009. 65: p. S124-S124.

Fujita, K., et al., Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. PLoS One, 2009. 4(9): p. e7247.

Fu, Y., et al., Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neuroscience Letters, 2009. 453: p. 81–85.

Sato, Y., et al., Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice . Biochem Biophys Res Commun, 2008. 375(3): p. 346-350.

Kashiwagi, T., et al., Suppression of Oxidative Stress-Induced Apoptosis of Neuronal Cells by Electrolyzed-Reduced Water. Animal Cell Technology Meets Genomics, 2005. 2: p. 257-260.

These scientific articles, although promising and interesting, do not represent clinical guidelines confirming that hydrogen can cure or prevent a particular disease. For medical questions, consult your doctor.

449.Chen, Y., et al., H Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain. Inflammation, 2015.

450.Chen, Q., et al., Hydrogen-rich saline attenuates neuropathic pain by reducing oxidative stress. Can J Neurol Sci, 2013. 40 (6): p. 857-63.

451. Ge, Y., et al., Intrathecal Infusion of Hydrogen-Rich Normal Saline Attenuates Neuropathic Pain via Inhibition of Activation of Spinal Astrocytes and Microglia in Rats. PLoS One, 2014. 9 (5): p. e97436.

452. Guan, Z., et al., Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells. Arch Gynecol Obstet, 2015.

453. Kawaguchi, M., et al., Molecular hydrogen attenuates neuropathic pain in mice. PLoS One, 2014. 9 (6): p. e100352.

454. Koseki, S. and K. Itoh, Fundamental properties of electrolyzed water. Journal of the Japanese Society for Food Science and Technology-Nippon Shokuhin Kagaku Kogaku Kaishi, 2000. 47 (5): p. 390-393.

455. Li, FY, et al., Consumption of hydrogen-rich water protects against ferric nitrilotriacetate-induced nephrotoxicity and early tumor promotional events in rats. Food Chem Toxicol, 2013. 61 : p. 248-54.

456. Morita, C., T. Nishida, and K. Ito, Biological toxicity of acid electrolyzed functional water: effect of oral administration on mouse digestive tract and changes in body weight. Arch Oral Biol, 2011. 56 (4): p. 359-66.

457. Sakai, T., et al., Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function. Vasc Health Risk Manag, 2014. 10 : p. 591-7.

458.Tsubone, H., et al., Effect of Treadmill Exercise and Hydrogen-rich Water Intake on Serum Oxidative and Anti-oxidative Metabolites in Serum of Thoroughbred Horses. J Equine Sci, 2013. 24 (1): p. 1-8.

459.Wang, WN, et al., [Regulatory effects of hydrogen-rich medium on monocytic adhesion and vascular endothelial permeability] . Zhonghua Yi Xue Za Zhi, 2013. 93 (43): p. 3467-9.

460. Yahagi, N., et al., Effect of electrolyzed water on wound healing. Artificial Organs, 2000. 24 (12): pp. 984-987.

461.Zhao, S., et al., Therapeutic effects of hydrogen-rich solution on aplastic anemia in vivo. Cell Physiol

Li, H., et al., Hydrogen-rich saline protects against small-scale liver ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress . Life Sci, 2018. 194: pp. 7-14.

Ishikawa, T., et al., Post-reperfusion hydrogen gas treatment ameliorates ischemia reperfusion injury in rat livers from donors after cardiac death: a preliminary study . Surg Today, 2018.

Chen, M., et al., Hydrogen protects against liver injury during CO2 pneumoperitoneum in rats. Oncotarget, 2018. 9(2): p. 2631-2645.

Zhai, X., et al., Hydrogen-rich saline improves nonalcoholic fatty liver disease by alleviating oxidative stress and activating hepatic PPARalpha and PPARgamma . Mol Med Rep, 2017. 15(3): p. 1305-1312.

Wang, D., et al., The protective role of hydrogen-rich saline against liver injury caused by acetaminophen in mice . Int J Clin Exp Med, 2017. 10(8): p. 11646-11654.

Uto, K., et al., Hydrogen Rich Solution Attenuates Cold Ischemia-Reperfusion Injury in Rat Liver Transplantation. Transplantation, 2017. 101(5S-3): p. S18.

Lin, CP, et al., Anti-oxidant and anti-inflammatory effects of hydrogen-rich water alleviate ethanol-induced fatty liver in mice . World J Gastroenterol, 2017. 23(27): p. 4920-4934.

Li, H., et al., Inhalation of high concentrations of hydrogen ameliorates liver ischemia/reperfusion injury through A2A receptor mediated PI3K-Akt pathway . Biochem Pharmacol, 2017. 130: p. 83-92.

Iketani, M., et al., Preadministration of Hydrogen-Rich Water Protects Against Lipopolysaccharide-Induced Sepsis and Attenuates Liver Injury . Shock, 2017. 48(1): p. 85-93.

Golshahi, H., et al., Protective effect of intraportal infusion of hypothermic hydrogen-rich saline solution on hepatic warm ischemia/reperfusion injury in rat model . Brazilian Journal of Veterinary Pathology, 2017. 10(1): p. 10-21.

Shimada, S., et al., Hydrogen Gas Ameliorates Hepatic Reperfusion Injury After Prolonged Cold Preservation in Isolated Perfused Rat Liver . Artif Organs, 2016. 40(12): p. 1128-1136.

Shi, Q., et al., Hydrogen-Rich Saline Attenuates Acute Hepatic Injury in Acute Necrotizing Pancreatitis by Inhibiting Inflammation and Apoptosis, Involving JNK and p38 Mitogen-Activated Protein Kinase-dependent Reactive Oxygen Species . Pancreas, 2016. 45(10): p. 1424-1431.

Liu, Q., et al., Hydrogen-rich saline protects against mitochondrial dysfunction and apoptosis in mice with obstructive jaundice . Mol Med Rep, 2016. 13(4): p. 3588-96.

Zhang, JY, et al., Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice. World J Gastroenterol, 2015. 21(14): p. 4195-209.

Zhang, CB, et al., Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-κB signaling pathway . Experimental and Therapeutic Medicine, 2015. 9(6): p. 2114-2120.

Yu, J., et al., Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression . Toxicol Lett, 2015. 238(3): p. 11-19.

Sobue, S., et al., Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents . Mol Cell Biochem, 2015. 403(1-2): p. 231-41.

Lee, PC, et al., Concomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen-rich saline and N-acetylcysteine ​​treatments improves systemic, splanchnic and hepatic hemodynamics of cirrhotic rats. Hepatol Res, 2015. 45(5): p. 578-88.

Tan, YC, et al., Hydrogen-rich saline attenuates postoperative liver failure after major hepatectomy in rats. Clin Res Hepatol Gastroenterol, 2014. 38(3): pp. 337-45.

Matsuno, N., et al., Beneficial effects of hydrogen gas on porcine liver reperfusion injury with use of total vascular exclusion and active venous bypass . Transplant Proc, 2014. 46(4): pp. 1104-6.

Liu, Y., et al., Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release . BMC Gastroenterol, 2014. 14: p. 12.

Koyama, Y., et al., Effects of oral intake of hydrogen water on liver fibrogenesis in mice. Hepatol Res, 2014. 44(6): p. 663-677.

Xu, XF and J. Zhang, Saturated hydrogen saline attenuates endotoxin-induced acute liver dysfunction in rats. Physiol Res, 2013. 62(4): p. 395-403.

Xia, C., et al., Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B. Clin Transl Sci, 2013. 6(5): p. 372-5.

Wang, W., et al., Effects of hydrogen-rich saline on rats with acute carbon monoxide poisoning . Journal of Emergency Medicine, 2013. 44(1): p. 107-15.

Liu, GD, et al., Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells. Int J Ophthalmol, 2013. 6(3): p. 280-5.

Xiang, L., et al., Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine. World Journal of Gastroenterology, 2012. 18(37): p. 5197-5204.

Nishimura, N., et al., Pectin and high-amylose maize starch increase caecal hydrogen production and relieve hepatic ischemia-reperfusion injury in rats. Br J Nutr, 2012. 107(4): p. 485-92.

Sun, H., et al., The protective role of hydrogen-rich saline in experimental liver injury in mice. Journal of Hepatology, 2011. 54(3): p. 471-80.

Shen, MH, et al., Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning. Medical Hypotheses, 2010. 75(2): p. 235-237.

Liu, Q., et al., Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice. Liver International, 2010. 30(7): p. 958-968.

Tsai, CF, et al., Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice . Food Chem Toxicol, 2009. 47(8): p. 2031-6.

Park, SK, et al., Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats. Biomed Res, 2009. 30(5): p. 263-9.

Kajiya, M., et al., Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. Biochem Biophys Res Commun, 2009. 386(2): p. 316-21.

Itoh, T., et al., Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells . Biochem Biophys Res Commun, 2009. 389(4): p. 651-6.

Gharib, B., et al., Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation. CR Acad Sci III, 2001. 324(8): p. 719-724.

Li, J., et al., Protective effects of molecular hydrogen on steroid-induced osteonecrosis in rabbits via reducing oxidative stress and apoptosis . BMC Musculoskeletal Disord, 2017. 18(1): p. 58.

Guo, J., et al., Hydrogen-rich saline prevents bone loss in diabetic rats induced by streptozotocin . Int Orthop, 2017. 41(10): p. 2119-2128.

Yamada, T., et al., Hydrogen supplementation of preservation solution improves viability of osteochondral grafts. ScientificWorldJournal, 2014. 2014: p. 109876.

Wan, WL, et al., An In Situ Depot for Continuous Evolution of Gaseous H2 Mediated by a Magnesium Passivation/Activation Cycle for Treating Osteoarthritis . Angew Chem Int Ed Engl, 2018.

Ostojic, SM, et al., Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries . Postgrad Med, 2014. 126(5): p. 187-95.

Sun, Y., et al., Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats. Osteoporos Int, 2013. 24(3): p. 969-78.

Li, DZ, et al., Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells . J Bone Miner Metab, 2013.

Guo, JD, et al., Hydrogen water consumption prevents osteopenia in ovariectomized rats. Br J Pharmacol, 2013. 168(6): p. 1412-20.

Cai, WW, et al., Treatment with hydrogen molecule alleviates TNFalpha-induced cell injury in osteoblasts . Mol Cell Biochem, 2013. 373(1-2): p. 1-9.

Xu, Z., et al., Anti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan induced paw oedema . J Inflamm (Lond), 2012. 9: p. 2.

Takeuchi, S., et al., Hydrogen may inhibit collagen-induced platelet aggregation: an ex vivo and in vivo study. Internal Medicine, 2012. 51(11): p. 1309-13.

Lekic, T., et al., Protective effect of hydrogen gas therapy after germinal matrix hemorrhage in neonatal rats. . Acta Neurochir Suppl, 2011. 111: p. 237-41.

Kubota, M., et al., Hydrogen and N-acetyl-L-cysteine ​​rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model . Investigative Ophthalmology and Visual Science, 2011. 52(1): p. 427-33.

Itoh, T., et al., Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages . Biochemical and Biophysical Research Communications, 2011. 411(1): p. 143-9.

Hanaoka, T., et al., Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide . Medical Gas Research, 2011. 1(1): p. 18.

Kawasaki, H., JJ Guan, and K. Tamama, Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials . Biochemical and Biophysical Research Communications, 2010. 397(3): p. 608-613.

These scientific articles, although promising and interesting, do not represent clinical guidelines confirming that hydrogen can cure or prevent a particular disease. For medical questions, consult your doctor.

Song, D., et al., Hydrogen rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats . Mol Med Rep, 2018. 18(2): p. 1925-1938.

Matsuoka, H., et al., Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension . Clin Exp Hypertens, 2018: p. 1-5

Feng, R., et al., Early Aerobic Exercise Combined with Hydrogen-Rich Saline as Preconditioning Protects Myocardial Injury Induced by Acute Myocardial Infarction in Rats. Appl Biochem Biotechnol, 2018.

Chi, J., et al., Inhalation of Hydrogen Attenuates Progression of Chronic Heart Failure via Suppression of Oxidative Stress and P53 Related to Apoptosis Pathway in Rats . Frontiers in Physiology, 2018. 9: p. 1026.

Chen, K., et al., Hydrogen-rich solution attenuates myocardial injury caused by cardiopulmonary bypass in rats via the Janus-activated kinase 2/signal transducer and activator of transcription 3 signaling pathway . Oncol Lett, 2018. 16(1): pp. 167-178.

Zalesak, M., et al., Molecular hydrogen potentiates beneficial anti-infarct effect of hypoxic postconditioning in isolated rat hearts: a novel cardioprotective intervention . Can J Physiol Pharmacol, 2017. 95(8): pp. 888-893.

Yang, J., et al., Hydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac dysfunction in rats . Mol Med Rep, 2017. 16(2): p. 1771-1778.

Tamura, T., et al., Efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II trial): study protocol for a randomized controlled trial . Trials, 2017. 18(1): p. 488.

Ridwan, RD, WS Juliastuti, and RD Setijanto, Effect of electrolyzed reduced water on Wistar rats with chronic periodontitis on malondialdehyde levels . Dental Journal (Majalah Kedokteran Gigi), 2017. 50(1): pp. 10-13.

Katsumata, Y., et al., The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction - First Pilot Study in Humans . Circ J, 2017.

Gao, Y., et al., Hydrogen Gas Attenuates Myocardial Ischemia Reperfusion Injury Independent of Postconditioning in Rats by Attenuating Endoplasmic Reticulum Stress-Induced Autophagy. Cell Physiol Biochem, 2017. 43(4): p. 1503-1514.

Gao, Y., et al., Hydrogen-rich saline attenuates hippocampus endoplasmic reticulum stress after cardiac arrest in rats . Neurosci Lett, 2017. 640: p. 29-36.

Chen, O., et al., High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of the PI3K/Akt1 pathway . Sci Rep, 2017. 7(1): p. 14871.

Zhang, Y., et al., Hydrogen (H2) Inhibits Isoproterenol-Induced Cardiac Hypertrophy via Antioxidative Pathways . Front Pharmacol, 2016. 7: p. 392.

Wang, P., et al., Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats . Shock, 2016. 46(3): p. 312-8.

Gao, Y., et al., Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis . Mediators Inflamm, 2016. 2016: p. 1320365.

Zhang, G., et al., Pharmacological postconditioning with lactic acid and hydrogen rich saline alleviates myocardial reperfusion injury in rats . Sci Rep, 2015. 5: p. 9858.

Yu, Y., et al ., Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin . Genet Mol Res, 2015. 14(2): p. 6202-12.

Wu, F., et al., Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice . Cardiovasc Pathol, 2015. 24(5): p. 294-303.

Song, G., et al., Molecular hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor-knockout mice . Free Radic Biol Med, 2015. 87: p. 58-68.

Song, G., et al., Hydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients With Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial . J Clin Endocrinol Metab, 2015. 100(7): p. 2724-33.

Jing, L., et al., Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats . Heart Lung Circ, 2015. 24(6): p. 602-10.

Chen, H., et al., Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway . Int Immunopharmacol, 2015. 28(1): p. 643-54.

Xie, Q., et al., Hydrogen gas protects against serum and glucose deprivation induced myocardial injury in H9c2 cells through activation of the NFE2 related factor 2/heme oxygenase 1 signaling pathway . Mol Med Rep, 2014. 10(2): p. 1143-9.

Wu, S., et al., Hydrogen-containing saline attenuates doxorubicin-induced heart failure in rats. Pharmazie, 2014. 69(8): p. 633-6.

Sakai, T., et al., Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function. Vasc Health Risk Manag, 2014. 10: p. 591-7.

Jing, L., et al., Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats . Heart Lung Circ, 2014.

Huo, TT, et al., Hydrogen-Rich Saline Improves Survival and Neurological Outcome after Cardiac Arrest and Cardiopulmonary Resuscitation in Rats . Anesth Analg, 2014.

Hayashida, K., et al., Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of Cardiac Arrest, Independent of Targeted Temperature Management . Circulation, 2014.

Drabek, T. and PM Kochanek, Improving outcomes from resuscitation: from hypertension and hemodilution to therapeutic hypothermia to H2 . Circulation, 2014. 130(24): p. 2133-5.

Shinbo, T., et al., Breathing nitric oxide plus hydrogen gas reduces ischemia-reperfusion injury and nitrotyrosine production in murine heart. Am J Physiol Heart Circ Physiol, 2013 305(4): pp H542-50.

Nagatani, K., et al., The Effect of Hydrogen Gas on a Mouse Bilateral Common Carotid Artery Occlusion. Brain Edema XV Acta Neurochirurgica Supplement 2013.

Fujii, Y., et al., Insufflation of hydrogen gas restrains the inflammatory response of cardiopulmonary bypass in a rat model . Artif Organs, 2013. 37(2): pp. 136-41.

Yoshida, A., et al., H(2) mediates cardioprotection via involvement of K(ATP) channels and permeability transition pores of mitochondria in dogs. Cardiovasc Drugs Ther, 2012. 26(3): pp. 217-26.

Sun, Q., et al., Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats . Cardiovasc Res, 2012. 94(1): p. 144-53.

Sakai, K., et al., Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine. Scandinavian Cardiovascular Journal, 2012. 46(3): p. 183-9.

Qin, ZX, et al., Hydrogen-rich saline prevents neointima formation after carotid balloon injury by suppressing ROS and the TNF-alpha/NF-kappaB pathway . Atherosclerosis, 2012. 220(2): p. 343-50.

Noda, K., et al., Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration. Transpl Int, 2012. 25(12): p. 1213-22.

Hayashida, K., et al., H(2) gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model. J Am Heart Assoc, 2012. 1(5): p. e003459.

Kasuyama, K., et al., Hydrogen-rich water attenuates experimental periodontitis in a rat model . J Clin Periodontol, 2011. 38(12): p. 1085-90.

Hayashi, T., et al., Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice . American Journal of Physiology – Heart and Circulatory Physiology, 2011. 301(3): p. H1062-9.

These scientific articles, although promising and interesting, do not represent clinical guidelines confirming that hydrogen can cure or prevent a particular disease. For medical questions, consult your doctor.

Zhu, Q., et al., Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques . Sci Rep, 2018. 8(1): p. 8051.

Zhang, B., et al., Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells . Int J Mol Med, 2018. 41(6): p. 3653-3661.

Tanaka, Y., Y. Saitoh, and N. Miwa, Electrolytically generated hydrogen warm water cleanses the keratin-plug-clogged hair-pores and promotes the capillary blood-streams, more markedly than normal warm water does . Med Gas Res, 2018. 8(1): p. 12-18.

Li, Q., Y. Tanaka, and N. Miwa, Effects of hydrogen-occluding-silica microparticles on wound repair and cell migratory behavior of normal human esophageal epitheliocytes . . Medical Gas Research, 2018. 8(2): p. 57.

Fang, W., et al., Hydrogen gas inhalation protects against cutaneous ischaemia/reperfusion injury in a mouse model of pressure ulcer . J Cell Mol Med, 2018.

Zhang, J., et al., Hydrogen-Rich Water Ameliorates Total Body Irradiation-Induced Hematopoietic Stem Cell Injury by Reducing Hydroxyl Radical . Oxid Med Cell Longev, 2017. 2017: p. 8241678.

Yan, WM, et al., The reason for the amelioration of N-methyl-N-nitrosourea-induced retinitis pigmentosa in rats by hydrogen-rich saline . Int J Ophthalmol, 2017. 10(10): p. 1495-1503.

Wu, CY, et al., Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress . Sci Rep, 2017. 7(1): p. 3606.

Tamaki, N., et al., Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model . Oxid Med Cell Longev, 2016. 2016: p. 5679040.

Sawajiri, M., et al., Drinking high-energy electrolytic water decreases internal radiation exposure caused by the Fukushima Daiichi Nuclear power plant disaster Nuclear Technology & Radiation Protection , 2016. 31(2): p. 173-178.

Guo, J., et al., Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice . Oxid Med Cell Longev, 2016. 2016: p. 1947819.

Abou-Hamdan, M., et al., Molecular hydrogen attenuates radiation-induced nucleobase damage to DNA in aerated aqueous solutions. Int J Radiat Biol, 2016. 92(9): p. 536-41.

Xiao, YD, et al., Synergistic effect of hyperbaric oxygen preconditioning and hydrogen-rich saline in ameliorating rat flap ischemia/reperfusion injury. Plastic and Aesthetic Research, 2015. 2(6): p. 332.

Wang, X., et al., Hydrogen-rich saline resuscitation alleviates inflammation induced by severe burn with delayed resuscitation . Burns, 2015. 41(2): p. 379-85.

Liu, YQ, et al., Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway. Reconstructive & Aesthetic Surgery, 2015.

Ishibashi, T., et al., Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases. Mol Med Rep, 2015. 12(2): pp. 2757-64.

Guo, SX, et al., Beneficial effects of hydrogen-rich saline on early burn-wound progression in rats. PLoS One, 2015. 10(4): p.e0124897.

Zhao, S., et al., Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction. J Cell Mol Med, 2014. 18(5): pp. 938-46.

Yoon, YS, et al., Positive Effects of hydrogen water on 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice. Biol Pharm Bull, 2014. 37(9): p. 1480-5.

Mei, K., et al., Hydrogen protects rats from dermatitis caused by local radiation . J Dermatologist Treat, 2014. 25(2): p. 182-8.

Yu, WT, et al., Hydrogen-enriched water restoration of impaired calcium propagation by arsenic in primary keratinocytes. Journal of Asian Earth Sciences, 2013. 77: p. 342-348.

Yang, Y., et al., Molecular hydrogen protects human lymphocyte AHH-1 cells against C heavy ion radiation. International Journal of Radiation Biology, 2013.

Shin, MH, et al., Atomic Hydrogen Surrounded by Water Molecules, H(H2O)m, Modulates Basal and UV-Induced Gene Expressions in Human Skin In Vivo . PLoS One, 2013. 8(4): p.e61696.

Li, Q., et al ., Hydrogen water intake via tube-feeding for patients with pressure ulcers and its reconstructive effects on normal human skin cells in vitro . Med Gas Res, 2013. 3(1): p. 20.

Jiang, Z., et al., Protection by hydrogen against gamma ray-induced testicular damage in rats . Basic Clin Pharmacol Toxicol, 2013. 112(3): pp. 186-91.

Ignacio, RM, et al., The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice . Molecular & Cellular Toxicology, 2013. 9(1): pp. 15-21.

Ignacio, RM, et al., The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides farinae Allergen in NC/Nga Mice. Evid Based Complement Alternative Med, 2013. 2013: p. 538673.

Yang, Y., et al., Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis. Med Sci Monit, 2012. 18(4): p. BR144-8.

Wei, L., et al., Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pigs. Experimental Eye Research, 2012. 94(1): p. 117-27.

Ono, H., et al., Hydrogen (H2) treatment for acute erythematous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers . Medical Gas Research, 2012. 2(1): p. 14.

Kato, S., et al., Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA rays together with type-I collagen production and oxidative-stress diminution in fibroblasts and cell-injury prevention in keratinocytes. J Photochem Photobiol B, 2012. 106: p. 24-33.

Guo, Z., et al., Hydrogen-rich saline protects against ultraviolet B radiation injury in rats . J Biomed Res, 2012. 26(5): p. 365-71.

Chuai, Y., et al., Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice. Med Sci Monit, 2012. 18(3): p. BR89-94.

Chuai, Y., et al., Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals. Biochemical Journal, 2012. 442(1): p. 49-56.

Zhao, L., et al., Hydrogen protects mice from radiation-induced thymic lymphoma in BALB/c mice . International Journal of Biological Sciences, 2011. 7(3): p. 297-300.

Yoon, KS, et al., Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless mice. Biological and Pharmaceutical Bulletin, 2011. 34(11): p. 1671-7.

Qian, LR, et al., Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage. Nuclear Technology & Radiation Protection, 2010. 25(1): p. 23-29.

Qian, LR, et al., Radioprotective effect of hydrogen in cultured cells and mice . Free Radic Res, 2010. 44(3): p. 275-282.

Kitamura, T., H. Todo, and K. Sugibayashi, Effect of several electrolyzed waters on the skin permeation of lidocaine, benzoic acid, and isosorbide mononitrate. Drug Development and Industrial Pharmacy, 2009. 35(2): p. 145-53.

These scientific articles, although promising and interesting, do not represent clinical guidelines confirming that hydrogen can cure or prevent a particular disease. For medical questions, consult your doctor.